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New approach methodologies (NAMs) are being evaluated for their utility to inform developmental neurotoxicity (DNT) hazard instead of using animals. This work compares predictive models for DNT using DNT NAMs data. The dataset comprised 200 chemicals screened in 17 DNT assays wit...

This is a public presentation on the potential effects of nutrients in smoke on downwind cyanobacteria blooms. Wildfire activity is increasing in the continental U.S. and can be linked to climate change effects, including rising temperatures and more frequent drought conditions. ...

The relationship between environmental chemical exposure and a spectrum of neurological diseases is well-established. However, unraveling the underlying mechanism between human exposure and toxic outcomes presents significant challenges. Evaluation of neurotoxicity potential usin...

The meeting aims to 1) discuss progress towards updating the Initial Recommendations to an OECD guidance, 2) discuss the regulatory implementation of the current DNT-IVB and strategy to include/exclude additional assays, and 3) discuss complementary aspects of the guidance that a...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

The US EPA has developed a set of annual North American anthropogenic and fire emissions data for criteria air pollutants across 18 broad source catagories for 2002 through 2017.  The sixteen new annual emissions inventories were developed using consistent input data and met...

Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making r...

Protein processing operations include animal slaughtering, meat and poultry product production, and/or rendering of byproducts. These facilities utilize large volumes of water for hair/hide/feather removal, carcass washing, chilling, trimming and cutting, cooking, and cleaning/sa...

Background:  Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...

Recent advances in high-resolution mass spectrometry (HRMS) have enabled the detection of thousands of chemicals from a single sample, while computational methods have improved the identification and quantification of these chemicals in the absence of reference standards typicall...

Accurate fire emissions inventories are crucial to predict the impacts of wildland fires on air quality and atmospheric composition. Two traditional approaches are widely used to calculate fire emissions: a satellite-based top-down approach and a fuels-based bottom-up approach. H...

Bacillus anthracis, the causative agent of inhalation anthrax, is one of the most highly studied biological threat agents. Significant gaps remain related to the remediation of a wide area following such biological release. This extends to the remediation of critical assets owned...

This is a talk I will give as part of the Toxics Webinar | Issue Cover Authors of 2023. I will only discuss published work that has been cleared and published in Toxics last year.

Critical loads or levels (CL) are estimates of quantitative thresholds for levels of deposition above which significant harmful ecological effects can occur, according to present knowledge.• Recent research focused on establishing CLs for tree species’ growth and survi...

Climate change presents cascading and compounding threats to low-income and underrepresented communities, increasing the need for equitable resilience planning. However, many local governments face challenges incorporating community voices with resilience and vulnerability data i...

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...

Increasing and inequitable impacts from climate change and other hazards are a growing concern for communities and a focus of planning efforts. This research, conducted through case studies with several U.S. communities, explores and develops ways to center equity in resilience p...

This presentation shares an overview of the research that ORD is planning to co-produce with the Crisfield, Maryland community and stakeholders to investigate options for nature-based solutions for coastal resilience. It presents preliminary research results from scoping potentia...

A critical step in systematic reviews of potential health hazards is the structured evaluation of the strengths and weaknesses of the included studies; risk of bias is a term often used to represent this process, specifically with respect to the evaluation of systematic errors th...

Subchronic and chronic studies in rats of the gasoline oxygenates ethyl tert-butyl ether (ETBE) and tert-butanol (TBA) report similar noncancer kidney and liver effects but differing results with respect to kidney and liver tumors. Because TBA is a major metabolite of E...

Gene drives are a topic of growing interest since the CRISPR/Cas9 system was discovered. In 2016, the National Academies published a report about science, governance, and engagement related to gene drive research and testing. There are valuable insights in all chapters, but espec...

With the declining tailpipe emissions from the US and worldwide motor vehicle fleet, impacts of tire and brake wear are an increasingly important area of interest.  Recent research has shown the compound 6PPD used in tires as an anti-degradation chemical reacts with ozone to...

This presentation summarizes perspectives from the U.S. Environmental Protection Agency’s 2023 Air Sensors Quality Assurance Workshop (https://www.epa.gov/air-sensor-toolbox/quality-assurance-air-sensors#QAworkshop). Air sensors can provide valuable non-regulatory and suppl...

Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research